To date, most toxicology tests have not been validated but they are still mandated by regulatory agencies. The question is to find suitable ways of modernising toxicology testing in the 21st century in a structured, consistent, transparent way. In this article, Thomas Hartung, Founder Evidence-Based Toxicology Collaboration (EBTC), at Johns Hopkins University Bloomberg School of Public Health, and colleagues, examine what remains to be done to address the mounting pressure exerted on industries and food and drug regulators worldwide to bring their decision-making process up-to-date with modern science. This calls for the use of a rigorous appraisal of the value of past studies under the umbrella of what has been dubbed evidence-based medicine (EBM), to be adapted in toxicology, to guarantee the safety of drug and consumer products. Read more [...]This post was viewed 54 times.